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  • 產(chǎn)品名稱(chēng):MyelinBasicProtein(MBP)(MiddleRegion)Peptide

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MyelinBasicProtein(MBP)(MiddleRegion)Peptide
詳情介紹:
Blocked Antibody anti-MBP antibody (Middle Region) (ABIN2786586)
Characteristics This is a synthetic peptide designed for use in combination with anti-MBP antibody (Catalog #: ARP56224_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Purification Purified
Background The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. MBP induces T-cell proliferation.The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called 'Golli-MBP') that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.

Alias Symbols: MGC99675

Protein Interaction Partner: MAPK1,PRKCA,PRKCD,PRKCI,PRKCZ,ROCK1,ROCK2,APTX,ATN1,ATXN1,BMP2K,CDK12,CLK1,CTDSP1,DYRK1B,EFHA1,HLA-DRA,IRAK1,MAG,MAPK1,MAPK11,MAPK13,MAPK14,MAPK15,MAPK3,MAPKAPK5,MELK,MKNK1,MMP7,MST4,NEK9,PAK1,PLP1,PRKACA,PRKCA,PRKCD,PRKCI,PRKCZ,PRMT1,PRMT5,RAN,RPS6KA5,RTN4,SRPK1,STK16,STK39,STK4,TLK1,TLK2,TRAF6,TRPM7,HLA-DRA,PLP1,PRMT5,STK39,TRPM7

Protein Size: 304
Molecular Weight 33 kDa
Gene ID 4155
NCBI Accession NM_001025101, NP_001020272
UniProt P02686
Research Area Neurology
Application Notes Each Investigator should determine their own optimal working dilution for specific applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100?μL of sterile PBS. Final peptide concentration is 1?mg/mL in PBS.
Concentration 1 mg/mL
Buffer Final peptide concentration is 1 mg/mL in PBS.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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