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  • 產品名稱:Rabbitanti-HumanIgG(FcRegion)Antibody

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  • 產品廠商:SXBIO
  • 產品文檔:
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簡單介紹:
Rabbitanti-HumanIgG(FcRegion)Antibody
詳情介紹:
Immunogen Human IgG Fc fragment
Isotype IgG
Purification Caprylic Acid Ammonium Sulfate Precipitation
Background The fragment crystallizable region (Fc region) is the tail region of an antibody that interacts with cell surface receptors called Fc receptors and some proteins of the complement system. This property allows antibodies to activate the immune system. InIgG, IgA and IgD antibody isotypes, the Fc region is composed of two identical protein fragments, derived from the second and third constant domains of the antibody two heavy chains, IgM and IgE Fc regions contain three heavy chain constant domains (CH domains 2-4) in each polypeptide chain. The Fc regions of IgGs bear a highly conserved N-glycosylation site. Glycosylation of the Fc fragment is essential for Fc receptor-mediated activity. The N-glycans attached to this site are predominantly core-fucosylated diantennary structures of the complex type. In addition, small amounts of these N-glycans also bear bisecting GlcNAc and α-2,6 linked sialic acid residues.
Synonyms: fragment crystallizable region
Research Area Immunology, Secondary Antibodies
Application Notes Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the investigator.
Restrictions For Research Use only
Format Liquid
Buffer 0.03 % Proclin 300, 50 % Glycerol, 0.01 M PBS, pH 7.4
Preservative ProClin
Precaution of Use This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Shipped at 4 °C. Upon delivery aliquot and store at -24 °C or -84 °C.
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